Institutional Repository of Radio Astronomy Research Laboratory
| 高分子混合刷吸附/脱附蛋白质的模型化研究 | |
| Alternative Title | Modeling study of adsorption/desorption of proteins by polymer mixed brush |
Liu Chun-Jie1; Zhao Xin-Jun1,2; Gao Zhi-Fu3 ; Jiang Zhong-Ying2
| |
| 2021-11-20 | |
| Source Publication | 物理学报
 |
| ISSN | 1000-3290 |
| Volume | 70Issue:22Pages:224701 |
| Contribution Rank | 3 |
| Abstract | Based on the diffusion dynamics, a new theoretical model is established to investigate the dynamic properties of a polymer mixed brush (PMB) in the protein adsorption/desorption process. The theoretical model considers the adsorption of proteins by one polymer chain (P-polymer chain) and the desorption of proteins by another polymer chain (N-polymer chain) in a PMB, as well as the time delay between adsorption and desorption. The dynamic properties of protein adsorption/desorption by a PMB depend on not only the chemical and physical properties of polymer chains, but also the microenvironment (density of protein in the solution and protein diffusivity) of the PMB. In order to describe the different chemical and physical properties of polymer chains and microenvironments in PMB, we take different model parameters, and obtain partial adsorption/desorption, complete adsorption/desorption and periodic adsorption/desorption of proteins by the PMB. By analyzing the process of protein adsorption/desorption in a PMB, we find that the microenvironment has an obvious influence on the adsorption and desorption of protein by the PMB. It is also shown that the adsorption of protein and the desorption of protein by the PMB have a stable and invariable periodic cycle when an alternating electric field is applied. The average adsorption capacity and the average desorption capacity increase in comparison with those when no electric field is applied. A stable alternating electric field enables the PMB to exhibit stable periodic dynamic characteristics in the dynamic process of protein adsorption and desorption. Our theoretical results are consistent with the experimental observations. Based on this, it is predicted that an external electric field can realize multiple cycles of protein adsorption and desorption by PMB, which provides necessary references and useful insights into controllable protein adsorption/desorption by the PMB in the practical applications. |
| Keyword | polymer mixed brush protein adsorption/desorption dynamic properties |
| DOI | 10.7498/aps.70.20211219 |
| Indexed By | SCI |
| Language | 中文 |
| WOS Keyword | SERUM-ALBUMIN ; ADSORPTION ; SURFACES ; KINETICS ; DENSITY ; DESIGN ; LAYERS |
| Funding Project | National Natural Science Foundation of China[22163011] ; Yi Li Normal University Doctoral Research Startup Foundation, China[2020YSBS008] ; Joint Funds of Xinjiang Natural Science Foundation, China[2019D01C333] |
| WOS Research Area | Physics |
| WOS Subject | Physics, Multidisciplinary |
| WOS ID | WOS:000732827600023 |
| Publisher | CHINESE PHYSICAL SOC |
| Funding Organization | National Natural Science Foundation of China ; Yi Li Normal University Doctoral Research Startup Foundation, China ; Joint Funds of Xinjiang Natural Science Foundation, China |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.xao.ac.cn/handle/45760611-7/4415 |
| Collection | 射电天文研究室_脉冲星研究团组 |
| Corresponding Author | Zhao Xin-Jun |
| Affiliation | 1.Yi Li Normal Univ, Xinjiang Lab Phase Transit & Microstruct Condence, Yining 835000, Peoples R China 2.Yi Li Normal Univ, Lab Micronano Elect Biosensors & Bion Devices, Yining 835000, Peoples R China 3.Chinese Acad Sci, Xinjiang Astron Observ, Urumqi 830011, Peoples R China |
| Recommended Citation GB/T 7714 | Liu Chun-Jie,Zhao Xin-Jun,Gao Zhi-Fu,等. 高分子混合刷吸附/脱附蛋白质的模型化研究[J]. 物理学报,2021,70(22):224701. |
| APA | Liu Chun-Jie,Zhao Xin-Jun,Gao Zhi-Fu,&Jiang Zhong-Ying.(2021).高分子混合刷吸附/脱附蛋白质的模型化研究.物理学报,70(22),224701. |
| MLA | Liu Chun-Jie,et al."高分子混合刷吸附/脱附蛋白质的模型化研究".物理学报 70.22(2021):224701. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 刘春杰-2021-高分子混合刷吸附_脱附（1876KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment